I'd just like to wish good luck to astronaut Scott Kelly and cosmonaut Mikhail Kornienko.
These two men will be spending a full year on the ISS to assess the potential effects on human health of long duration space travel - such as a trip to Mars. (I'm a little disappointed they chose two men for the first experiment and I hope somebody will realize that we do need to repeat this with a woman - our plumbing is a little different, after all).
They will be looking at things like eyes (the shape of the eyeball changes in microgravity), gut bacteria, etc. Hopefully they won't have the kind of major problems that might delay our efforts to get off this rock until we come up with reasonable gravity simulation (from spin or otherwise).