"Locked-in" - the body is completely paralyzed and the mind intact. It's a nightmare - but the first success using a brain implant to allow such a patient to communicate has been announced.
The "brain chip" lets Hanneke de Bruijne type at about two words per minute on a special computer - which sounds awful, but it's better than nothing. They are now hoping to provide the device to others.
Maybe one day we'll have "lock ins" able to chat on the internet with the rest of us.